Chengdu International Railway Port serves as the departure point for the China-Europe (Chengdu) Railway Express and other services have been provided to address cross-border logistical concerns and international transit between Sichuan and members of the Association of Southeast Asian Nations.

In 2022, the city launched the China-Vietnam Railway Express and the China-Laos Railway Express.

The debut of the Mandalay-Chengdu intermodal train in mid-June marked the opening of a new China-Myanmar route that connects Chengdu to Southeast Asia via the Tengchong Houqiao Port in Yunnan province. It has provided a crucial link between China, Myanmar and the rest of Southeast Asia.

As of mid-2023, the city's international railway express has extended its reach to 30 cities in China and 100 foreign destinations, serving as the hub of a network of rail routes and a land-sea freight distribution that connects Western Europe to the west, Mongolia and Russia to the north, Japan and South Korea to the east, and ASEAN countries to the south.

By the end of April, a total of 22,000 international freight trains departed from Chengdu to other parts of the world.