Lady First, a talk show about women's issues, will be broadcast on 30 video websites, more than 100 television networks and some mobile media.
Producer Yi Shu claims it's the mainland's most expensive talk show, costing more than $1.5 million a year. Guests will be "the women most talked about by men" and "the men most talked about by women", he says.
The first guests include photographer Chen Man and singer Yang Yuying, who has returned to the entertainment industry after 11 years.
Taiwan star Nancy Kou will host the show, which will premiere on March 8.